Technion teams have solved a major problem in the manufacture of “repairing” tissues and organs
A revolutionary technology for cultivating artificial biological tissues for transplantation has been developed by Technion research teams.
The study led by Shulamit Levenberg and Majd Machour, from the Faculty of Biomedical Engineering, and by Havazelet Bianco-Peled and Noy Hen, from the Wolfson Faculty of Chemical Engineering and the Norman Seiden Multidisciplinary Graduate Program in Nanoscience and Nanotechnology, was published in a journal article Advanced Science last month.
With this technique, also called bio-printing, living cells are embedded in biological ink and printed layer by layer. The printed fabric is then grown in a microgel matrix for days or weeks until it is ready for use.
“Many research groups around the world are working on improving the printing of fabrics, but most of them focus on the printing phase and the initial product – the printed fabric. However, the Tissue growth – i.e. the period between printing and transplantation into the target organ – is no less important,” explains Professor Levenberg.
“This is a complex period in which the imprinted cells divide, migrate, secrete their extracellular matrix and attach to each other to create the tissue. One of the problems is that in this process complex, the fabrics tend to deform and shrink in an uncontrolled way”, she specifies.
The Technion teams, by reproducing the complex structure of living tissues while maintaining their stability (size and shape), have solved a major problem in the manufacture of “repairing” tissues and organs.